Best Probiotic Strain For Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder known for its painful and frustrating symptoms, including stomach cramps, abdominal pain, bloating, flatulence, and irregular bowel movements. (1,2)*

Growing evidence suggests that the gut microbiome contributes to developing IBS. Studies have shown notable differences in gut bacteria between individuals with and without IBS. (3) Furthermore, those with IBS have reduced diversity in their gut bacteria, indicating fewer bacterial types. (4)

Are you looking for a probiotic to help manage your IBS symptoms? Continue reading to learn more about the best probiotic for IBS.*

What is IBS?

Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by recurring abdominal pain or discomfort associated with altered bowel habits. The symptoms of IBS can vary from person to person, but they often include abdominal pain, bloating, gas, diarrhea, and constipation. (1,2)*

There are four subcategories of IBS:

  • IBS with diarrhea (IBS-D): This is the most common form of IBS, characterized by frequent episodes of loose or watery stools.
  • IBS with constipation (IBS-C): This form of IBS is characterized by infrequent hard and lumpy stools.
  • IBS with mixed bowel habits (IBS-M): This form of IBS is characterized by inconsistent bowel habits that are a combination of diarrhea and constipation.
  • IBS-unclassified (IBS-U): This form of IBS does not fit into any of the other categories.

The exact cause of IBS is unknown; however, it is thought to be caused by a combination of factors, including genetics, the gut microbiome, and stress. While there is no definitive cure for IBS, there are various treatments to help manage symptoms. These treatments include lifestyle changes, medications, and dietary changes.

According to the American College of Gastroenterology, approximately 10-15% of adults in the United States experience IBS symptoms, yet only 5-7% receive an official IBS diagnosis. (1) If you suspect you may have IBS, it is essential to consult a doctor for proper diagnosis and treatment.

Nevertheless, there is a reason for hope, as support is readily accessible!

Probiotics can offer potential relief for this frequently incapacitating health condition. To effectively manage IBS, it is important to choose the right probiotic. Keep reading to learn how probiotics can help manage IBS symptoms.*

Probiotic stats for US adults

The IBS-Microbiome Connection

The gut microbiome is the community of bacteria that live in your gut. It plays an essential role in digestion, immunity, and overall health. People with irritable bowel syndrome (IBS) often have an imbalance in their gut microbiome, which can contribute to their symptoms. (4)

There is increasing evidence that the gut microbiome may play a role in irritable bowel syndrome (IBS). Studies have shown that people with IBS have different types of gut bacteria than people who do not have IBS. (3) Specifically, people with IBS may have lower levels of beneficial bacteria, such as Bifidobacterium and Lactobacillus, and higher levels of harmful bacteria, such as Bacteroides and Enterobacteriaceae. (5) These bacterial levels can fluctuate based on the subcategories of IBS.

A few things can disrupt the gut microbiome, including stress, diet, and antibiotics. If you have IBS, maintaining a healthy gut microbiome is essential. You can do this by eating a healthy diet, managing stress, and avoiding antibiotics unless necessary.

Here are some ways to support your gut health:

  • Eat a healthy diet with plenty of fruits, vegetables, and whole grains.
  • Avoid processed foods, sugary drinks, and excessive caffeine and alcohol.
  • Manage stress through exercise, yoga, or meditation.
  • Take probiotics, which are live bacteria that can help to improve gut health.*

Talk to your healthcare provider if you are concerned about your gut health. They can help you to determine if you have IBS and recommend treatment options.

Choosing the Best Probiotic for IBS Symptoms*

The probiotic market is experiencing tremendous growth, with projections indicating that probiotic supplements in North America will triple by 2027, reaching $1.5 billion. (6)

Within the probiotic market, a wide range of products support various health needs. These options include dental probioticsprobiotics for agingpregnancy, and everyday gut health.*

When looking for the best probiotics for IBS, or any health condition, it’s important to consider the following five criteria.*

1. Strain Precision

Precision Probiotics is a science-based approach to probiotic manufacturing. What the research shows is that when it comes to probiotics, more is not always better. Instead, it’s about using the right strain for the proper indication. It’s not about numbers but precision in selecting suitable probiotic strains.

Therefore, the potency of a probiotic in terms of colony-forming units (CFUs) is less important than the specific probiotic strains incorporated into the formula. In fact, too high of a CFU count can aggravate IBS symptoms in some people.

Here at Hyperbiotics, we believe in the power of precision when formulating. PRO-IBS Support* is our cutting-edge probiotic supplement designed specifically to help manage the symptoms of moderate IBS.*

PRO-IBS Support* is our advanced probiotic formula specifically designed for people with IBS. It contains science-backed ingredients that address occasional IBS symptoms, including diarrhea, constipation, bloating, and abdominal pain.*

2. Scientific Evidence

When choosing a probiotic formula for IBS, it is crucial to consider the scientific evidence. Not all strains of probiotics are equally beneficial for all conditions, and some strains may even aggravate the symptoms of IBS.

Researchers have made significant progress in identifying potential solutions for effectively managing moderate IBS symptoms. One notable discovery is the effectiveness of a specific probiotic known as LP299V®, which is supported by over 65 different clinical studies. (7) Additionally, Boswellia serrata, a widely studied nutraceutical, has shown promise in addressing IBS. (8)* 

Click here or keep reading to learn more about the science behind these two ingredients.

3. Benefits

“Different strains for different pains” is rooted in our philosophy at Hyperbiotics. We specialize in Precision Probiotics – selecting the right probiotic strain for the right indication.

We formulated PRO-IBS Support* with a blend of Lactiplantibacillus plantarum 299v and Boswellia serrata extract. These clinically studied ingredients work synergistically to reset and support the gut, promoting improved gut function, regularity, and overall well-being for individuals seeking effective digestive support.*

4. Transparency

A transparent ingredient list offers precise information about the contents of a product, enabling you to make informed choices about what you consume. At Hyperbiotics, you can trust that what you see on the label is precisely what you’ll receive.

Our clean, vegan, non-GMO formulas are free from gluten, dairy, soy, egg, peanut, tree nut, fish, shellfish, active yeast, and unnecessary excipients. Our formulas leverage research-backed, clinically effective strains for precise results you can feel.*

5. Affordability & Convenience

We understand the importance of convenience and affordability when taking supplements. We know how to streamline our production process to create high-quality probiotics at an affordable price. Our commitment to efficiency allows us to pass on savings to you.

We also know that shelf stability is essential for convenience. Many probiotics need to be stored in the refrigerator, which can make them inconvenient to travel with and remember to take. At Hyperbiotics, we use the latest science to deliver shelf-stable probiotics that maintain their potency at room temperature. This means you can take our probiotics anywhere, anytime, without worrying about refrigeration.

Everyone deserves access to high-quality probiotics tailored to their needs regardless of their budget. That’s why we’re committed to providing Precision Probiotics that are effective, safe, and affordable.

Best Probiotic for IBS*

Like many things in life, there is a spectrum of symptoms and severities associated with Irritable Bowel Syndrome (IBS).

If you’ve ever experienced the discomfort of constipation or diarrhea, then you can relate to the frustration that arises from their unpredictability.

Conventional treatments for IBS often involve strict dietary limitations or a range of medications. However, these approaches may not effectively address the underlying cause of the problem.

An imbalance in the gut microbiome may contribute to the symptoms of IBS, such as abdominal pain, bloating, and diarrhea. Studies indicate that probiotics, which are live bacteria resembling the “good” bacteria naturally present in the gut, can help to restore gut microbiome balance and improve IBS symptoms. (9)*

More research is needed to fully understand the gut microbiome’s role in IBS. Still, the available evidence suggests that gut bacteria are an important factor in the development and severity of the condition. Therefore, working with a qualified healthcare practitioner is important to determine the right supplements for you.

A healthcare practitioner can help you assess your individual needs and recommend a supplement that is likely to be effective. They can also monitor your progress and adjust the dosage as needed. It is important to note that supplements are not a substitute for medical care. If you are experiencing symptoms of IBS, seeing a doctor to rule out other medical conditions is crucial.

PRO-IBS Support* – Precision Probiotics for IBS*

Crafted with precision, we formulated PRO-IBS Support* as an advanced, dual-action blend designed to effectively stabilize gut discomfort and dysfunction in those with IBS. This synergistic combination formula provides a more effective solution than stand-alone probiotics by providing accelerated and prolonged relief from occasional bloating, gas, and irregularity.*

What’s in PRO-IBS Support*?

PRO-IBS Support* combines a strategic blend of Lactiplantibacillus plantarum 299v and highly bioavailable Boswellia serrata extract. These clinically studied ingredients work synergistically to reset and support the gut, promoting improved gut function, regularity, and overall well-being for individuals seeking effective digestive support.*

Lactiplantibacillus plantarum 299v (LP299V®):

  • A patented and trademarked probiotic strain commonly found in the normal intestinal microbiota of healthy adults. It is one of the market’s most widely researched probiotic strains and has been studied in IBS populations.
  • Backed by over 65 clinical studies, with more scientific studies emerging.
  • Possesses a unique ability to survive the harsh conditions of the gastrointestinal tract and adhere to gut wall cells, supporting a healthy intestinal barrier.*
  • Provides essential nutritional support for gastrointestinal health, occasional abdominal discomfort, bloating, and gas, as well as the management of moderate IBS.*

Boswellia serratta extract:

  • A highly bioavailable, sunflower lecithin-based form of Boswellia serrata extract for enhanced utilization and absorption.*
  • Boswellia interacts with the intestinal microflora within the gastrointestinal tract to support the gut’s metabolic processes and establish a healthy gut microbiome.*
  • Works synergistically within the gut alongside the intestinal microflora to address imbalances associated with diarrhea and constipation-like IBS states.*
  • Helps address occasional bloating, gas, and regularity of gut function.*
  • Supports healthy inflammatory responses.*

In only one capsule daily, PRO-IBS Support* delivers 30 billion CFUs of Lactiplantibacillus plantarum 299v (LP299V®) and 125mg of lecithin-based Boswellia serrata extract for advanced IBS support.*

How Do The Ingredients Work Together?

Lactiplantibacillus plantarum 299v (LP299V®) and Boswellia serrata work synergistically to:

  • Stabilize gut discomfort and dysfunction in IBS patients*
  • Provide accelerated and prolonged relief from occasional bloating, gas, and irregularity*
  • Support healthy gut function and regularity*
  • Provide effective digestive support*

Why It’s the Best Probiotic for IBS

  • Science-Backed: Delivers a blend of well-researched ingredients that have been studied in IBS patients.
  • Clean formula: Free from major allergens, including gluten, dairy, soy, egg, peanut, tree nut, fish, and shellfish. Free from artificial flavors, artificial colors, active yeast, and preservatives.
  • Vegan and vegetarian-friendly
  • Shelf-stable
  • Only 1 capsule daily
PRO-IBS Support

PRO-IBS Support* – FAQs

Have questions? Keep reading to find answers to the most frequently asked questions about PRO-IBS Support*, or reach out to us anytime.

What’s in PRO-IBS Support*?

Two ingredients: Lactiplantibacillus plantarum 299v (LP299V®) and Boswellia serrata extract.

Does this help with all types of IBS (C, D, M, U)? 

The subtypes of IBS, characterized by diarrhea, constipation, or a combination of both, can be supported by improving gut function, colonization of effective healthy probiotic strains, and availability of phytonutrients that support the metabolomic profile of the gut microbiome.*

PRO-IBS Support* delivers a key probiotic strain identified as a “cornerstone” species for a healthy microbiome and is safe for use in any subtype of IBS. Specifically, studies on LP299V® have been done in the IBS-D, IBS-M, and IBS-C subtypes, and Boswellia has been studied in the general IBS population. (10,11)*

Can I take this if I don’t have IBS?

Yes. While PRO-IBS Support* is designed for individuals with IBS, it’s also suitable for those seeking adequate digestive and gut function support.*

This product contains a probiotic strain identified as a “cornerstone” species of the gut, meaning it is essential species found in all healthy microbiomes. Since every person’s microbiome is unique, those without IBS may benefit from adding this product to their daily regimen for gut health and microbiome rebalance.*

Can I take this with other formulas? 

PRO-IBS Support* is safe to take with other Hyperbiotics Precision Probiotics since it contains unique ingredients not found in our other products. For any additional questions, please consult a healthcare provider.

Do the strains survive stomach acid?

LP299V® has been studied in humans and is efficacious and survives stomach acids when delivered in a vegetable capsule. (12) 

Do I need to refrigerate it?

No, this product is stable for 24 months at room temperature.

Can it cure or treat IBS?

As defined by the FDA, dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. PRO-IBS Support* was formulated to support healthy structures and functions in the gastrointestinal tract and has been studied in IBS populations. The functional issues associated with IBS are effectively addressed, allowing for the restoration of regularity and alleviating bloating and gas caused by improved gut function.*

Does it have a prebiotic? Do I need to take prebiotics with it? 

While Boswellia is not classified as a prebiotic, it does provide synergetic benefits for the probiotic, providing a faster response in supporting a healthy microbiome and improved gut function important to those with IBS. The probiotic can colonize and balance the gut microflora without a specific prebiotic, but the gut microbiome may be improved due to the combination.*

What is the best time of the day to take it?

There are no specific recommendations on what time of day to take PRO-IBS Support*. However, it should be taken regularly at the same time daily to ensure the probiotic is being delivered to the gut regularly.

What side effects can I expect?

If probiotics and digestive support products are new to you, then a transition in use could be helpful. For the first week, consider taking the product every other day. In week 2, try transitioning to taking every day. Check with your healthcare provider in advance for any concerns or more specific directions.

Can children take this formula?

Both ingredients in this formula have been studied in children and are generally safe. However, it is always best to consult with your pediatrician before giving any new supplements to your child.

Is it safe to take while pregnant or breastfeeding?

These ingredients have not been studied in a pregnant or breastfeeding population. While these ingredients are safe for consumption, pregnant or breastfeeding consumers should consult their healthcare provider before use.

Is PRO-IBS Support* GMP-certified?

Our products are manufactured in Washington and Colorado in GMP-certified facilities through NSF. We adhere to the strictest quality control and FDA guidelines and perform rigorous testing on every lot to ensure they are survivable and as the label states.


Emerging research indicates that the gut microbiome plays a role in IBS development, with individuals experiencing differences in gut bacteria and reduced bacterial diversity. Probiotics have shown promise in restoring microbial balance and managing IBS symptoms.*

Hyperbiotics offers PRO-IBS Support*, a precision probiotic formulated with Lactiplantibacillus (lactobacillus) plantarum 299v and Boswellia serrata extract to support gut function, regularity, and overall well-being, providing relief from occasional bloating, gas, and irregularity.*

PRO-IBS Support* is backed by scientific research, made with clean ingredients, and is convenient to take with its shelf-stability. While it’s crucial to consult a healthcare practitioner for personalized advice, PRO-IBS Support* offers a promising solution for individuals with moderate IBS symptoms.*


  1. Am J Gastroenterol. 2021; 116(1):17-44 [PMID: 33315591]
  2. Benef Microbes. 2021; 12(5):441-465 [PMID: 34365915]
  3. Dig Dis Sci. 2020; 65(3):829-839 [PMID:32026278]
  4. Microbiol Spectr. 2023; 11(1):e0212522 [PMID: 36652592]
  5. Adv Ther. 2018; 35(3): 289–310 [PMID: 29498019]
  6. Statista. Nils-Gerrit Wunsch. 2022
  7. Z Gastroenterol. 2021; 59(2):125-134 [PMID: 33556972]
  8. Nutrients. 2022; 14(3): 416 [PMID: 35276778]
  9. Cureus. 2022; 14(4): e24240 [PMID: 35602835]
  10. J Pak Med Assoc. 2022; 72(3):404-408 [PMID: 35320214]
  11. Minerva Gastroenterol Dietol. 2019; 65(1):30-35 [PMID: 30676012]
  12. World J Gastroenterol. 2012; 18(30):4012-8 [PMID: 22912552]

*These statements have not been evaluated by the Food and Drug (FDA) Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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